Immunisation with non-integral OMPs promotes pulmonary clearance ofPseudomonas aeruginosa
نویسندگان
چکیده
منابع مشابه
Immunisation with non-integral OMPs promotes pulmonary clearance of Pseudomonas aeruginosa.
Pseudomonas aeruginosa is an opportunistic bacterial pathogen that can cause fatal acute lung infections in critically ill individuals. Lung damage due to chronic infections in cystic fibrosis sufferers is the major cause of morbidity and mortality in this group. The bacterium produces various immunomodulatory products that enable it to survive in the lung. Innate and increasing resistance to a...
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Lumican is an extracellular protein that associates with CD14 on the surface of macrophages and neutrophils, and promotes CD14-TLR4 mediated response to bacterial lipopolysaccharides (LPS). Lumican-deficient (Lum(-/-)) mice and macrophages are impaired in TLR4 signals; raising the possibility that lumican may regulate host response to live bacterial infections. In a recent study we showed that ...
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BACKGROUND While the functional consequences of acute pulmonary infections are widely documented, few studies focused on chronic pneumonia. We evaluated the consequences of chronic Pseudomonas lung infection on alveolar function. METHODS P. aeruginosa, included in agar beads, was instilled intratracheally in Sprague Dawley rats. Analysis was performed from day 2 to 21, a control group receive...
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ژورنال
عنوان ژورنال: FEMS Immunology & Medical Microbiology
سال: 2003
ISSN: 0928-8244,1574-695X
DOI: 10.1016/s0928-8244(03)00073-7